The effects described in the book were accurate initially but then diverted from the most likely clinical outcome (death).Īlthough Dahl ought to be applauded for his initial accuracy about the toxicology of the ingredients in George's marvellous medicine, the overall effect would be fatal catastrophic physiological collapse. Potentially life threatening effects were associated with 13 (38%) ingredients, including depression of the central nervous system, kidney injury, convulsions, cardiac toxicity, and mucosal erosion. The most common toxic effect identified on ToxBase was nausea and vomiting (16 ingredients, 47%). Two literature loving households in England.Ĭlinical and toxic effects of the individual ingredients checked against those listed in ToxBase, the National Poisons Information Service's poisons database. To analyse the therapeutic effects and toxicity of the eponymous concoction described in Roald Dahl's book George's Marvellous Medicine.
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